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The Fruit and Vegetable Section

Oral Allergy Syndrome: Why do Pollens and Foods Cross-React?

178184870Photo: Thinkstock

If trees make you sneeze, they may also make you react to certain fruits and vegetables.

Allergic Living explores the science behind oral allergy syndrome, nature’s allergic double whammy.

Not only do a third of North Americans battle hay fever – with runny noses, sinus and eye symptoms – but for a significant proportion of allergy sufferers, the spring bloom is just the start of their allergy woes. Dr. Antony Ham Pong, a Canadian allergist and researcher, estimates that up to 10 per cent of the general population has a condition called oral allergy syndrome, or OAS.

It’s a less severe form of food allergy, directly related to pollen reactions, that’s known to set off tingling and unpleasant itching in the mouth, throat and lips. Reactions are caused by a variety of fruits, vegetables, nuts, seeds, and even spices; all of which share allergenic proteins with specific hay fever-causing trees and plants.

“It’s not considered a life-threatening allergy,” says Ham Pong, the author of several articles educating patients and doctors about oral allergy syndrome. “But it’s actually more common than peanut, milk, egg, and fish allergy.”

Two of the biggest cross-reaction offenders are birch and alder trees. Depending on where you live, anywhere from 20 to 70 per cent of people who are allergic to birch and alder pollens will also have oral allergy syndrome.

Ham Pong estimates about one-third of birch-allergic North Americans are affected, but the incidence of oral allergy syndrome is even higher in some European countries. Although OAS is relatively common, he doesn’t think it is increasing, at least not in North America. Rather, doctors have become better at spotting this condition.

But how can a tall, skinny tree that gives you the sniffles cause an itchy mouth if you chew on a celery stick or bite into an apple?

How the immune system gets confused

Unfortunately for those with tree-pollen allergies, the pollen proteins that trigger hay fever symptoms are also found in a several foods.

The components of those proteins are well conserved among different plants, which means their three-dimensional structures are so similar that some of our immune systems can’t tell the difference between, say, birch pollen and apple peel.

In birch, the most common allergy troublemaker is a protein called Bet v 1, and alder has a similar protein called Aln g 1. Their purpose is to help protect the fruit or vegetable in times of stress or from infection.

Ham Pong explains that Bet v 1 is called a “pan-allergen” because very similar proteins are found in a variety of unrelated plants, including apples, plums, kiwis, carrots, celery, potatoes, hazelnuts, almonds, sunflower seeds, and even spices such as oregano, basil and dill.

People with birch-related oral allergy syndrome already produce antibodies to the pan-allergens from their prior exposure to birch pollen, so those antibodies will try to protect against similar proteins when they enter the mouth.

Next: Trouble with apples, peaches



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