Something was causing him to experience unnerving allergic reactions, sometimes in the middle of the night. His skin felt “on fire” with welts that would swell and itch – but what was behind the outbreaks? And how to stop them?

After consulting a physician and keeping a log of every morsel he ate for months, Grisham uncovered the bizarre cause of his misery: red meat (beef, pork and other mammals’ meat). What he didn’t know at the time was that the allergy is linked to tick bites. And Virginia, where Grisham’s family lives on a farm, is tick central.

In fact, University of Virginia researchers were among the first to document the tick-meat allergy connection, in part because renowned UVA allergist Dr. Thomas Platts-Mills himself developed meat allergy after being bitten by ticks.

What makes the allergy particularly confounding to track is that it causes delayed reactions, often over four hours after eating meat.

Despite his busy schedule of writing, speaking, and supporting good causes, Grisham manages to keep his allergy in check both at home (in Virginia and Mississippi) and on the road.

He has three new books being released in 2012, including a baseball novel, Calico Joe, and the third installment in his young adult series, featuring “kid lawyer” Theodore Boone (who happens to have asthma), but the author still found time to sit down in his Charlottesville, Virginia office with Allergic Living contributor Mary Esselman.

With good humor and frequent reference to his meticulous log notes, Grisham discussed his bedeviling allergy.

On the beginning of his odd allergy.

“The first [reaction] was in June of 2002. I noticed some rashes on my ankles. I remember thinking, ‘This is weird, both ankles.’” [He didn’t think it was a big deal.]

“Then in July 2002, I went with my wife to an annual garden club dinner, and she had prepared these huge beef tenderloins that I had grilled. And while I was cooking, I was shaving some off to sample. By the time we got to the garden club party, my ears were really, really itching. I got my wife and said, ‘Renee, something’s going on.’

There was a doctor there, and he gave me an antihistamine. My skin was on fire.

So we got in the car, and I was so desperate I stripped down, took off all my clothes but my boxer shorts, and I had all the air [conditioning vents] blowing on me, and you could just see the welts. The skin was just welting up. It almost made me nauseated just watching my skin.”

[He wrote down in the food log his doctor advised him to keep that it was beef. The penny began to drop.] “It was always beef.”

Next Page: ‘I woke up and thought I was going to die’

But a new study could change that. Researchers at Monash University in Australia are working on a dust-mite vaccine that, if successful, would have the potential to cure sufferers in just two to three doses. Professor Els Meeusen is applying her experience in infectious disease vaccines to the world of allergy. She believes the addition of a new ingredient into the vaccine could be the magic bullet allergy sufferers have been waiting for.

Allergic Living’s Kim Shiffman spoke with Els Meeusen to find out what that ingredient is, and when the vaccine might be available.

Why focus on immunotherapy as a treatment for dust mite allergy?

It’s the only treatment that could be a cure. All the others are just to keep allergic symptoms under control, but they don’t cure anything.

How would your vaccine be different than the one that’s been available for years?

The current house dust mite allergy vaccine is given at continuously increasing doses over a period of years. You have to be very careful giving it – it can be a little bit dangerous to use because it’s not well known how it works, and if you don’t use it properly, it could cause a serious reaction. It’s also not quite clear if or when it’s going to start working, and there are no clear markers to actually assess if it’s working.

What our work will do is try to speed up the vaccine effect, a bit like in the work I do with infectious diseases, where you only have to give two or three injections before you get good immunity. If we can achieve the same immune deviation – changing the immune system by vaccination using the same principles as infectious diseases – then we may be able to have a more effective and quicker vaccination regime for house dust mite allergy.

Next Page: More questions on the vaccine

DECORATING

1. Scented Candles
The thought of cinnamon or vanilla wafting through the house may appeal, but scented candles smell of big trouble for those with allergies or chemical sensitivities.

“People who have environmental allergies such as to pollen or pets develop very sensitive inflamed nasal tissue which is hyper-reactive,” explains Ottawa allergist Dr. Antony Ham Pong. “These tissues then react more strongly to scents, and act as if they are allergens and mimic an allergic reaction.”

Plus, consider whether soy-allergic guests will be visiting before you light up that soy wax candle. While most are made from hydrogenated oil, which won’t cause an inhalant reaction, your soy-allergic guest or her child may feel uncomfortable knowing that a soy product is wafting through the air.

Advice: Use unscented, beeswax candles or opt instead for trendy fairy light strings for table décor or wreaths.

2. Festive Spores
If you have environmental allergies, a pine or cedar dominating the living room can bring you to sneezes and tears (or worse). Allergists warn at this time of year about “Rudolph the Reindeer Syndrome,” literally a reaction to the Christmas tree.

“Allergic reactions can occur to any pollen from the pine cones, or to mold in the bark of the tree,” Dr. Ham Pong notes. He says the tree’s resin can also cause “either eczema from contact with the skin, or nasal symptoms due to the scent.”

Mold is the biggest issue – some studies suggest household mold counts can increase as much as 10 times with a cut tree in the home. But an artificial tree can also harbor mold if it was stored in a damp basement.

Advice: Reduce the allergen load of a fresh-cut tree with a good blow-out – either taking it home on the roof of your car or subjecting it to a leaf blower on your front lawn. This gets rid of pollen grains and some mold. If mold is an asthma trigger, the Asthma and Allergy Foundation of America additionally suggests wiping around the tree’s trunk with a solution of 1 part bleach to 20 parts of lukewarm water. Also, wear gloves when moving a tree or boughs to avoid contact with the sap.

Or: Opt instead for a nice faux tree. Just be sure to enclose it plastic post-season, and store it in a dry spot.

3. Up in Smoke
Watch out for a roaring wood fire when visiting. As Certified Asthma Educator Jo-Anne St. Vincent has explained in Allergic Living magazine, that can expose those with asthma or allergies to a variety of environmental triggers, including smoke and mold.

If visiting friends in a home with a trendy enclosed gas fireplace, that’s a safer bet. But even then don’t linger close by. Vincent says gas-burning fireplaces still emit nitrogen oxide, which can increase inflammation of the airways.

While manufactured fireplace logs used to be infamous for off-gassing toxic chemicals (since industrial waste was part of their composition), today these logs are much more environmentally friendly. There are still two problems though from an allergy/asthma perspective:

a) smoke, no matter how “green” still irritates sensitive airways.
b) Nut allergy concerns. Several brands make “crackling” fire logs, and they use walnut or other nut shells to achieve the sound while burning. It’s wise to avoid putting such proteins into the air around a nut-allergic individual.

Advice: Best of all is to ask close family to forego the fire in the living room, if that’s to be the main party room.

Next: Gift Giving, Food and Drink Tips

You can’t see them, but they’re all over your home. Dust mites will be in the carpet, the sofa, the bedding, the curtains, even a child’s stuffed animals. These tiny insects, visible only under a microscope, leave a trail of waste that is a highly allergenic.

It’s estimated that between 10 and 25 per cent of North Americans are sensitized to dust mite droppings, and that these pests will spark wheezing in over 50 per cent of asthmatics. Thankfully, while you can’t get rid of dust mites completely, you can minimize their multiplying numbers.

What They Are

Dust mites, cousins to the spider, are tiny, eight-legged arachnids measuring only one-quarter to one-third of a millimetre in size. They spend their two to four months of life eating, creating waste and reproducing. A female will lay 100 eggs in her lifetime, and each mite produces about 10 to 20 waste pellets a day.

They are whitish in color, and thrive in warmth (between 24 and 26 degrees C; 75 and 80 degrees F) and humidity higher than 50 per cent. Mites eat minuscule flakes of human skin and animal dander. They can’t drink, but absorb moisture from the atmosphere.

Where They Live

Dust mites prefer a plentiful supply of skin flakes or animal dander, moisture and warmth. This is why you’ll find the highest concentration of mites in your bed. An average mattress contains between 100,000 and 10 million bugs.

A study in 2000 found that more than 45 per cent of American homes had detectable dust mite levels associated with the development of allergies, and 23 per cent had bedding with concentrations of allergen high enough to trigger asthma attacks.

Next Page: What You Can Do