A study published in the July issue of Clinical Pediatrics found that in cities, almost 9.8 percent of young people have food allergies, while only 6.2 percent of rural kids had this condition. Shellfish allergies were three times as common in city kids and peanut allergies were double the farm incidence.

Using data from a survey of 38,465 young people from infancy to age 18, “we have found for the first time that higher population density corresponds with a greater likelihood of food allergies in children,” says lead author Dr. Ruchi Gupta, an assistant professor of pediatrics at Northwestern University’s Feinberg School of Medicine and a physician at the Ann & Robert H. Lurie Children’s Hospital of Chicago. Previously, similar demographic trends have been found for the incidence of environmental allergies and asthma.

The study, funded by the Food Allergy Initiative (FAI), effectively “maps” the occurrence of food allergy across the United States. The states with the highest rates of food allergy (greater than 9.5 percent) were Florida, Georgia, Nevada, New Jersey, Delaware, Maryland and Alaska. Gupta is also the author of a 2011 study that found 8 percent of children across the United States have food allergies.

In an interview with Allergic Living, Gupta notes intriguing trends that need more investigation. For instance, in her Q&A with editor Gwen Smith, she says she is fascinated to find a greater tendency to have food allergy in southern states – which she agrees is contrary to studies that find vitamin D in areas with stronger sun exposure may protect against allergies. She also sees proximity to water as a variable that deserves more scrutiny.

Next page: Q&A on Food Allergy’s Traits

The study, funded by the Food Allergy Initiative and to be published in the journal Pediatrics, finds that 9.8 percent of city kids have food allergies – compared to 6.2 percent with the condition in rural areas. The study involved 385,465 children under the age of 18 and is the first large-scale study to map food allergies across the United States.

“This shows that environment has an impact on developing food allergies,” Gupta said in a news release.

Among her findings:

• A 3.5 percent higher incidence of food allergies in city-dwelling children compared to rural-dwellings kids.

• Peanut allergies are twice as common in the city-living children. (2.8 percent compared to 1.3 percent).

• Shellfish allergies are more than double in the city children.

Allergic Living magazine will have a full report on this study in its Fall 2012 edition. Haven’t subscribed yet? It’s easy to do here.

An estimated 2.5 percent of Americans – 7.5 million people – have at least one food allergy and young black children with asthma appear to be at the highest risk, according to findings from what is believed to be the largest food allergy study to date. The research was conducted by investigators at Johns Hopkins Children’s Center, the National Institutes of Health and other institutions.

The findings, published in the October issue of the Journal of Allergy and Clinical Immunology, are based on blood samples and interviews with more than 8,200 participants, ages 1 to older than 60, in whom investigators searched for the prevalence of four food allergies and for links between food allergies and asthma, eczema and hay fever.

Previous research has found slightly higher numbers of national food allergy prevalence, but the researchers say a true comparison between the new and the previous findings would not be meaningful because of different methodologies, different criteria and different population sizes.

Besides the sheer size of this new study, one of its strengths, the researchers say, was the use of blood levels of antibodies as an indicator of actual disease rather than theoretical risk, making it the first of its kind to use that standard in thousands of participants. Indeed, only people with levels high enough to suggest clinical disease were classified as allergic.

Overall, 2.5 percent of the people in the study had a blood test indicating a food allergy. The most common allergy was to peanuts, with 1.5 percent of people testing highly positive for peanut antibodies, the proteins made by the immune system in response to allergens.

These were followed by shrimp (1 percent), eggs (0.4 percent) and milk (0.2 percent). Many (1.3 percent) had more than one type of allergy. Overall, allergies were most common in children 5 years old or younger, with 4.2 percent of them testing highly positive for one, followed by those between ages 6 and 19 (3.8 percent).

“This study is comprehensive in its scope and is the first to use specific blood serum levels and look at food allergies across the whole life spectrum,” says study senior investigator Darryl Zeldin, M.D., acting clinical director at the National Institute of Environmental Health Sciences (NIEHS).

In the study, children under the age of 5 were more than twice as likely as those older than 20 to have a food allergy and black people were three times as likely as white people to have one, while men were nearly 1.9 times more likely than women to be affected.

Black boys were more than four times as likely as white women over 20 to have a food allergy.

The findings also show that food allergies were more common in those with asthma. While the researchers did not study cause and effect between food allergies and asthma, having a food allergy appeared to compound the risk for asthma and vice versa.

Those with asthma had nearly four times the risk of having a food allergy than those without it. Overall, people with food allergies were nearly seven times more likely than those without them to have required ER treatment for their asthma in the 12 months leading up to the study.

“Our findings confirm a long-suspected interplay between food allergies and asthma, and that people with one of the conditions are at higher risk for the other,” says investigator Robert Wood, M.D., director of Allergy and Immunology at Hopkins Children’s.

Wood notes that many children experience an “allergic march,” developing a food allergy first and getting asthma and hay fever later.

While people with food allergies were somewhat more likely to be diagnosed with hay fever, the link between the two was not particularly strong, and they did not appear to have higher risk for eczema, the investigators found.

Andrew H. Liu, M.D., of National Jewish Health hospital and the University of Colorado, was the lead investigator on the study.